Platr4^em#Dlsp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Platr4^em#Dlsp
• Name: pluripotency associated transcript 4; endonuclease-mediated mutation, David L Spector
• MGI ID: MGI:7388290
• Gene: Platr4 Location: Chr3:41442116-41447634 bp, - strand Genetic Position: Chr3, 19.85 cM
• Alliance: Platr4^em#Dlsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331476
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using two sgRNAs targeting the transcription start site and the first exon generated a knock-out. Three lines were generated from founders A1, A2, and A7. This record represents pooled data from these three lines. (J:331476)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Platr4 Mutation: 0 strains or lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:331476 Hazra R, et al., Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev Cell. 2022 Nov 7;57(21):2450-2468.e7
• All: 1 reference(s)