Tmem45b^em1Tkwa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem45b^em1Tkwa
• Name: transmembrane protein 45b; endonuclease-mediated mutation 1, Tomoyuki Kawamata
• MGI ID: MGI:7388444
• Gene: Tmem45b Location: Chr9:31337492-31375758 bp, - strand Genetic Position: Chr9, 16.9 cM
• Alliance: Tmem45b^em1Tkwa page

Mutation origin

• Strain of Origin: ((C57BL/6 x C3H)F1 x C57BL/6N)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• CRISPR-targeting generated a null allele by deleted the end of exon 2 through exon 4. (J:331496)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tmem45b^em1Tkwa/Tmem45b^em1Tkwa	involves: C3H * C57BL/6N

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
behavior/neurological	√
abnormal nociception after inflammation	√
nervous system	√
abnormal neuron morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem45b Mutation: 57 strains or lines available

References

• Original: J:331496 Tanioku T, et al., Tmem45b is essential for inflammation- and tissue injury-induced mechanical pain hypersensitivity. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2121989119
• All: 1 reference(s)