Tg(Myh11-cre/ERT2)F31Gko
Transgene Detail

Summary

• Symbol: Tg(Myh11-cre/ERT2)F31Gko
• Name: transgene insertion F31, Gary K Owens
• MGI ID: MGI:7398497
• Synonyms: Myh11-CreER(T2)-RAD, Myh11-CreER^T2-RAD
• Transgene: Tg(Myh11-cre/ERT2)F31Gko Location: unknown
• Alliance: Tg(Myh11-cre/ERT2)F31Gko page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Myh11-cre/ERT2)F31Gko expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh11 (MGI:102643)

• Mutation details: A bacterial artificial chromosome (BAC; RP23-151J22) containing the mouse smooth muscle myosin, heavy polypeptide 11 (Myh11) gene was used to insert a cre/ERT2 sequence (a mutated human estrogen receptor ligand binding domain fused to Cre) at the start codon of Myh11. The founder line F31, in which the transgene integrated into mouse Chromosome 2 in a region devoid of other genes [Chr2:178,826,578-178,826,802 (GRCm39)], was identified. (J:332260)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh11 (mouse) Summary of all recombinase alleles driven by Myh11. Comparative matrix view of recombinase activities Alliance mouse Myh11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:332260 Deaton RA, et al., New Autosomal Myh11-CreERT2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model. Arterioscler Thromb Vasc Biol. 2022
• All: 1 reference(s)