In(11)2Smun
Endonuclease-mediated Allele Detail

Summary

• Symbol: In(11)2Smun
• Name: inversion, Chr 11, Stefan Mundlos 2
• MGI ID: MGI:7407295
• Synonyms: InvCdeltaBor
• Gene: In(11)2Smun Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion, Inversion
• Mutation details: Border (insulator) region Rr325 in In(11Rr325)1Smun inversion allele ES cells (originally located between the Kcnj and Sox9 topologically associated domains (TADs)), was targeted with sgRNAs (targeting ATCCCGAAATTAAACTGCCC and CTTCTTAACAAAAACCGAAC) using CRISPR/Cas9 technology, resulting in its deletion. (J:282642)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any In(11)2Smun Mutation: 0 strains or lines available

References

• Original: J:282642 Despang A, et al., Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture. Nat Genet. 2019 Aug;51(8):1263-1271
• All: 1 reference(s)