Mrpl39^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mrpl39^em1(IMPC)J
• Name: mitochondrial ribosomal protein L39; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7408163
• Gene: Mrpl39 Location: Chr16:84515068-84532261 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3.3
• Alliance: Mrpl39^em1(IMPC)J page
• IMPC: Mrpl39 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GGGACTCCCGATGATTTAGA and GTTAAAAATGACTTTGCATG, which resulted in a 600 bp deletion beginning at Chromosome 16 position 84,732,127 bp and ending after 84,732,726 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000131646 (exon 3) and 460 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 90 and early truncation 20 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mrpl39 Mutation: 22 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)