Gt(ROSA)26Sor^{tm1(Stat6*)Voeh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Stat6*)Voeh}
• Name: signal transducer and activator of transcription 6; targeted mutation 1, David Voehringer
• MGI ID: MGI:7408247
• Synonyms: Rosa26^LSL-STAT6vt
• Gene: Stat6 Location: Chr10:127478855-127496826 bp, + strand Genetic Position: Chr10, 74.59 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Stat6*)Voeh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312747
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A loxP-flanked Stop cassette and a constitutively active STAT6 (contains a valine to alanine change at amino acid 547 and threonine to alanine change at amino acid 548) with a C-terminal FLAG-tag were inserted into the locus. (J:312747)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat6 Mutation: 51 strains or lines available

References

• Original: J:312747 Haase P, et al., Modulation of the humoral immune response by constitutively active STAT6 expression in murine B cells. Eur J Immunol. 2020 Apr;50(4):558-567
• All: 3 reference(s)