Arih1^em3Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arih1^em3Gpt
• Name: ariadne RBR E3 ubiquitin protein ligase 1; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd
• MGI ID: MGI:7408549
• Synonyms: Arih1^fl
• Gene: Arih1 Location: Chr9:59295541-59393901 bp, - strand Genetic Position: Chr9, 32.01 cM, cytoband C
• Alliance: Arih1^em3Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exon 3. (J:330879)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arih1 Mutation: 33 strains or lines available

References

• Original: J:330879 Xiong TC, et al., The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Nat Commun. 2022 Oct 10;13(1):5973
• All: 1 reference(s)