Grm3^tm1.1Conn
Targeted Allele Detail

Summary

• Symbol: Grm3^tm1.1Conn
• Name: glutamate receptor, metabotropic 3; targeted mutation 1.1, P Jeffery Conn
• MGI ID: MGI:7411111
• Synonyms: Grm3^Fl
• Gene: Grm3 Location: Chr5:9535541-9775170 bp, - strand Genetic Position: Chr5, 3.69 cM
• Alliance: Grm3^tm1.1Conn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332165
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct is designed to insert a loxP site upstream of exon 3 and a FRT-flanked neomycin resistance cassette, followed by a second loxP site, inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette. (J:332165)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grm3 Mutation: 55 strains or lines available

Notes

ES cells = C57BL/6J-derived FLP embryonic stem cells

References

• Original: J:332165 Dogra S, et al., Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus. Biol Psychiatry. 2021 Mar 6
• All: 1 reference(s)