Del(15Rr316124-Rr313939)2Fsp
Transposon induced Allele Detail

Summary

• Symbol: Del(15Rr316124-Rr313939)2Fsp
• Name: deletion, Chr 15, Francois Spitz 2
• MGI ID: MGI:7411151
• Synonyms: del(15-17), Myc^delta15-17
• Gene: Del(15Rr316124-Rr313939)2Fsp Location: unknown Genetic Position: Chr15, Syntenic

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Transposon induced (Conditional ready, Modified regulatory region, Reporter)
• Mutations: Insertion, Intergenic deletion
• Del(15Rr316124-Rr313939)2Fsp involves 13 genes/genome features (Gm20740, Gm25702, Gm4942 ...) View all
• Mutation details: Cre-mediated inter-chromosomal recombination between Tn(sb-SBlac)15.192339Fsp at chr15:63332129-63332130 (GRCm39) and Tn(sb-SBlac)15.179039Fsp at chr15:63590844-63590845 deleted approximately 259 kb and leaves one intact copy of the transposon cassette (in forward orientation) at the deletion junction. The transposon consists of a Sleeping Beauty transposon inverted repeat, loxP site, human beta-globin HBB minimal promoter, the lacZ beta-galactosidase reporter gene, SV40 poly(A) signal sequence, and a Sleeping Beauty transposon direct repeat. The deleted sequence is part of the Myc topologically associating domain (TAD) and contains Myc enhancers Rr316124, Rr313933, Rr331, Rr307328, Rr332, Rr307330, Rr333 and Rr313939. (J:212391)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(15Rr316124-Rr313939)2Fsp Mutation: 0 strains or lines available

References

• Original: J:212391 Uslu VV, et al., Long-range enhancers regulating Myc expression are required for normal facial morphogenesis. Nat Genet. 2014 Jul;46(7):753-8
• All: 2 reference(s)