Mirc30^em1Hhzg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mirc30^em1Hhzg
• Name: microRNA cluster 30, including Mir16-1 through Mir15a; endonuclease-mediated mutation 1, Xiao-yan Zhou
• MGI ID: MGI:7411324
• Synonyms: miR-15a/16-1^fl
• Gene: Mirc30 Location: Chr14:61869329-61869559 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320883
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed the microRNA cluster. (J:320883)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc30 Mutation: 4 strains or lines available

References

• Original: J:320883 Hutter K, et al., Differential roles of miR-15a/16-1 and miR-497/195 clusters in immune cell development and homeostasis. FEBS J. 2021 Mar;288(5):1533-1545
• All: 2 reference(s)