Lrrc63^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc63^em1(IMPC)J
• Name: leucine rich repeat containing 63; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7411383
• Gene: Lrrc63 Location: Chr14:75321743-75368321 bp, - strand Genetic Position: Chr14, 39.59 cM, cytoband D2
• Alliance: Lrrc63^em1(IMPC)J page
• IMPC: Lrrc63 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CTGCTTCCCAGAATAAATGA and GCATCCATGCCACTTAGCCA, which resulted in a 602 bp deletion beginning at Chromosome 14 position 75,122,674 bp and ending after 75,123,275 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000122811 (exon 5) and 441 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 321 and early truncation 20 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lrrc63 Mutation: 35 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)