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Lrrc63em1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: Lrrc63em1(IMPC)J
Name: leucine rich repeat containing 63; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:7411383
Gene: Lrrc63  Location: Chr14:75321743-75368321 bp, - strand  Genetic Position: Chr14, 39.59 cM, cytoband D2
Alliance: Lrrc63em1(IMPC)J page
IMPC: Lrrc63 gene page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CTGCTTCCCAGAATAAATGA and GCATCCATGCCACTTAGCCA, which resulted in a 602 bp deletion beginning at Chromosome 14 position 75,122,674 bp and ending after 75,123,275 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000122811 (exon 5) and 441 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 321 and early truncation 20 amino acids later. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lrrc63 Mutation:  35 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory