Rr1367^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr1367^em1Cya
• Name: regulatory region 1367; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7413089
• Synonyms: Peak16^-
• Gene: Rr1367 Location: Chr11:111459352-111460265 bp, . strand Genetic Position: Chr11, Syntenic
• Alliance: Rr1367^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The cranial neural crest cell (CNCC) specific Sox9 enhancer (chr11:111459349-111460265 (GRCm39)) was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a 1170 bp deletion that includes the enhancer. (J:332097)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr1367 Mutation: 0 strains or lines available

References

• Original: J:332097 Chen Q, et al., Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects. Sci Adv. 2022 Nov 25;8(47):eabo3648
• All: 1 reference(s)