Del(11Rr1367-Rr238931)1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(11Rr1367-Rr238931)1Cya
• Name: deletion, Chr 11, Cyagen Biosciences 1
• MGI ID: MGI:7413090
• Synonyms: PRS^-
• Gene: Del(11Rr1367-Rr238931)1Cya Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The Pierre Robin Sequence (PRS) region (chr11:111446352-111723870 (GRCm39)), which is part of the Sox9 topologically associating domain (TAD) that contains enhancers and other regulatory sequences, was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in its deletion. (J:332097)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Rr1367-Rr238931)1Cya Mutation: 0 strains or lines available

References

• Original: J:332097 Chen Q, et al., Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects. Sci Adv. 2022 Nov 25;8(47):eabo3648
• All: 1 reference(s)