Amigo2tm1Lti
Targeted Allele Detail
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| Symbol: |
Amigo2tm1Lti |
| Name: |
adhesion molecule with Ig like domain 2; targeted mutation 1, Li Tian |
| MGI ID: |
MGI:7413858 |
| Gene: |
Amigo2 Location: Chr15:97142006-97145168 bp, - strand Genetic Position: Chr15, 52.91 cM
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| Alliance: |
Amigo2tm1Lti page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:332202
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The whole coding region was replaced with human placental alkaline phosphatase gene and a neomycin resistance gene under the promoter of the Amigo2 gene. Absence of transcript expression was confirmed by RT-PCR. This is a null allele. RT-qPCR also showed no changes in Amigo1 or Amigo3 mRNA levels suggesting no compensation from the other Amigos.
(J:332202)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Amigo2 Mutation: |
25 strains or lines available
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| Original: |
J:332202 Li Z, et al., AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis. Brain Behav Immun. 2017 May;62:110-123 |
| All: |
2 reference(s) |
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Analysis Tools
