Actb^{tm1(icre)Ksak}
Targeted Allele Detail

Summary

• Symbol: Actb^{tm1(icre)Ksak}
• Name: actin, beta; targeted mutation 1, Kenji Sakimura
• MGI ID: MGI:7423624
• Synonyms: Actb-iCre
• Gene: Actb Location: Chr5:142888870-142892509 bp, - strand Genetic Position: Chr5, 81.8 cM
• Alliance: Actb^{tm1(icre)Ksak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267307
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Actb^{tm1(icre)Ksak} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Actb (MGI:87904)

• The targeting construct inserted the improved cre recombinase gene. (J:267307)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Actb (mouse) Summary of all recombinase alleles driven by Actb. Alliance mouse Actb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actb Mutation: 53 strains or lines available

References

• Original: J:267307 Zhou L, et al., Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype. J Neurochem. 2018 Nov;147(4):557-572
• All: 5 reference(s)