Morc2a^tm1.2Pngr
Targeted Allele Detail

Summary

• Symbol: Morc2a^tm1.2Pngr
• Name: microrchidia 2A; targeted mutation 1.2, Josef M Penninger
• MGI ID: MGI:7423696
• Synonyms: Morc2a^delta
• Gene: Morc2a Location: Chr11:3599191-3640477 bp, + strand Genetic Position: Chr11, 2.56 cM
• Alliance: Morc2a^tm1.2Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332344
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The KOMP vector PG00072_X_1_H08 inserted the FRT-flanked lacZ/neomycin resistance cassette with a 3' loxP site upstream of exon 4 and an additional loxP site down stream of exon 4. Flp-mediated recombination removed the reporter and selection cassette. Cre-mediated recombination removed exon 4. (J:332344)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Morc2a Mutation: 59 strains or lines available

References

• Original: J:332344 Hagelkruys A, et al., The HUSH complex controls brain architecture and protocadherin fidelity. Sci Adv. 2022 Nov 4;8(44):eabo7247
• All: 1 reference(s)