Del(3)1Jfm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(3)1Jfm
• Name: deletion, Chr 3, James F Martin 1
• MGI ID: MGI:7424889
• Synonyms: Pitx2^delta20k
• Gene: Del(3)1Jfm Location: unknown Genetic Position: Chr3, Syntenic

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: The Pitx2 AF (atrial fibrillation)-related enhancer, located upstream of the gene, was targeted with sgRNAs (targeting GTATTTCATCTAAGGCACAG and CATGGTCACAGTCAATGTGC) using CRISPR/Cas9 technology, resulting in an ~18.6 kb deletion. The deleted sequence contains predicted enhancer Rr79124. (J:281534)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(3)1Jfm Mutation: 0 strains or lines available

References

• Original: J:281534 Zhang M, et al., Long-range Pitx2c enhancer-promoter interactions prevent predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22692-22698
• All: 1 reference(s)