Adgra1^tm1.1Zgwg
Targeted Allele Detail

Summary

• Symbol: Adgra1^tm1.1Zgwg
• Name: adhesion G protein-coupled receptor A1; targeted mutation 1.1, Zhugang Wang
• MGI ID: MGI:7425047
• Gene: Adgra1 Location: Chr7:139414090-139458004 bp, + strand Genetic Position: Chr7, 84.89 cM
• Alliance: Adgra1^tm1.1Zgwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329982
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector inserted a loxP upstream of exon 4 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 4. Cre-mediated recombination removed the selection cassette and exon 4. Cre-mediated recombination removed the selection cassette and exon 4. (J:329982)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgra1 Mutation: 42 strains or lines available

References

• Original: J:329982 Zhang XH, et al., ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice. Cell Death Dis. 2021 Apr 6;12(4):362
• All: 2 reference(s)