Dgcr8^em1Ysa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dgcr8^em1Ysa
• Name: DGCR8, microprocessor complex subunit; endonuclease-mediated mutation 1, Yumiko Saga
• MGI ID: MGI:7425336
• Gene: Dgcr8 Location: Chr16:18071812-18107110 bp, - strand Genetic Position: Chr16, 11.31 cM, cytoband B1
• Alliance: Dgcr8^em1Ysa page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• CRISPR-targeting of exons 4 and 5 generated a null allele. (J:329565)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dgcr8 Mutation: 67 strains or lines available

References

• Original: J:329565 Kim J, et al., The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing. PLoS Genet. 2022 Oct;18(10):e1009967
• All: 1 reference(s)