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Del(7Mrgpra2a-Mrgpra2b)1Xzd
Endonuclease-mediated Allele Detail
Summary
Symbol: Del(7Mrgpra2a-Mrgpra2b)1Xzd
Name: deletion, Chr 7, Xinzhong Dong 1
MGI ID: MGI:7427349
Synonyms: Mrgpra2 dKO
Gene: Del(7Mrgpra2a-Mrgpra2b)1Xzd  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, No functional change)
Mutation:    Insertion
  Del(7Mrgpra2a-Mrgpra2b)1Xzd involves 2 genes/genome features (Mrgpra2a, Mrgpra2b) View all
 
Mutation detailsCRISPR-targeting of the 5UTR of one gene through the 3UTR of the other gene deleted both coding regions. (J:332494)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(7Mrgpra2a-Mrgpra2b)1Xzd Mutation:  0 strains or lines available
References
Original:  J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory