Del(8Defa1-Def)2Xzd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(8Defa1-Def)2Xzd
• Name: deletion, Chr 8, Xinzhong Dong 2
• MGI ID: MGI:7427351
• Synonyms: Def^flox
• Gene: Del(8Defa1-Def)2Xzd Location: unknown Genetic Position: Chr8, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Del(8Defa1-Def)2Xzd involves 149 genes/genome features (Gm36166, Defb40, Defb37 ...) View all
• Mutation details: CRISPR-targeting inserted a loxP site in exon 2 of Defb40 and Defb13 to generate a conditional allele. (J:332494)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(8Defa1-Def)2Xzd Mutation: 0 strains or lines available

References

• Original: J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
• All: 1 reference(s)