Mbd1^em1Heise
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mbd1^em1Heise
• Name: methyl-CpG binding domain protein 1; endonuclease-mediated mutation 1, Mark T Heise
• MGI ID: MGI:7427527
• Gene: Mbd1 Location: Chr18:74400676-74415803 bp, + strand Genetic Position: Chr18, 50.7 cM
• Alliance: Mbd1^em1Heise page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• A 752bp deletion spanning exons 11 and 13 of the Mbd1 gene was generated via CRISPR mutagenesis. (J:332559)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbd1 Mutation: 33 strains or lines available

References

• Original: J:332559 Hampton BK, et al., Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis. PLoS Genet. 2022 Dec;18(12):e1010548
• All: 1 reference(s)