Adamtsl3^em1Apte
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adamtsl3^em1Apte
• Name: ADAMTS-like 3; endonuclease-mediated mutation 1, Suneel Apte
• MGI ID: MGI:7427743
• Gene: Adamtsl3 Location: Chr7:81984902-82263658 bp, + strand Genetic Position: Chr7, 47.18 cM
• Alliance: Adamtsl3^em1Apte page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 5 bp deletion (GACAG) in exon 2 (encoding the signal peptide). (J:332622)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamtsl3 Mutation: 90 strains or lines available

References

• Original: J:332622 Rypdal KB, et al., ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFbeta signalling after pressure overload. Commun Biol. 2022 Dec 20;5(1):1392
• All: 1 reference(s)