Rnf217^tm1.1Fudi
Targeted Allele Detail

Summary

• Symbol: Rnf217^tm1.1Fudi
• Name: ring finger protein 217; targeted mutation 1.1, Fudi Wang
• MGI ID: MGI:7428715
• Synonyms: Rnf217^flox
• Gene: Rnf217 Location: Chr10:31377883-31485721 bp, - strand Genetic Position: Chr10, 17.45 cM
• Alliance: Rnf217^tm1.1Fudi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315675
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-flanked PGK-neomycin selection cassette and second loxP site were inserted downstream of exon 1. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 1 floxed. (J:315675)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf217 Mutation: 18 strains or lines available

References

• Original: J:315675 Jiang L, et al., RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation. Blood. 2021 Aug 26;138(8):689-705
• All: 1 reference(s)