Zfp746^tm1.1Tmd
Targeted Allele Detail

Summary

• Symbol: Zfp746^tm1.1Tmd
• Name: zinc finger protein 746; targeted mutation 1.1, Ted M Dawson
• MGI ID: MGI:7428903
• Synonyms: PARIS/ZNF746^-
• Gene: Zfp746 Location: Chr6:48039329-48063527 bp, - strand Genetic Position: Chr6, 23.04 cM
• Alliance: Zfp746^tm1.1Tmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327648
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of the 3UTR. Exons 5 to 7 and the 3UTR were deleted via cre-mediated recombination. (J:327648)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp746 Mutation: 22 strains or lines available

References

• Original: J:327648 Brahmachari S, et al., Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain. 2019 Aug 1;142(8):2380-2401
• All: 2 reference(s)