Ptprc^em1(dre)Bzsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptprc^em1(dre)Bzsh
• Name: protein tyrosine phosphatase receptor type C; endonuclease-mediated mutation 1, Bin Zhou
• MGI ID: MGI:7429135
• Synonyms: CD45-Dre
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^em1(dre)Bzsh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Ptprc^em1(dre)Bzsh expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ptprc (MGI:97810)

• Mutation details: Using CRISPR/Cas9, the cDNA encoding Dre recombinase was inserted into the Ptprc gene locus to replace the endogenous translational start codon followed by a transcriptional stop polyA sequence. (J:332772)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ptprc (mouse) Summary of all recombinase alleles driven by Ptprc. Alliance mouse Ptprc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 190 strains or lines available

References

• Original: J:332772 Jin H, et al., Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nat Commun. 2021 May 17;12(1):2863
• All: 1 reference(s)