Rr124128^tm1.1Jfer
Targeted Allele Detail

Summary

• Symbol: Rr124128^tm1.1Jfer
• Name: regulatory region 124128; targeted mutation 1.1, Jorge Ferrer
• MGI ID: MGI:7431269
• Synonyms: Haster^f, Haster (HNF1A-AS1) LoxP
• Gene: Rr124128 Location: Chr5:115106000-115110601 bp, . strand Genetic Position: Chr5, Syntenic
• Alliance: Rr124128^tm1.1Jfer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332319
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Modified regulatory region)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted upstream of the Hnf1aos1 gene promoter/1st exon and a second loxP site downstream of the Hnf1aos2 gene promoter/1st exon. These exons, promoters and loxP sites are located in Hnf1a intron 1. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with Hnf1aos1 and Hnf1aos2 promoters floxed. (J:332319)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr124128 Mutation: 0 strains or lines available

References

• Original: J:332319 Beucher A, et al., The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol. 2022 Oct;24(10):1528-1540
• All: 2 reference(s)