About   Help   FAQ
Zmynd8em1Lwb
Endonuclease-mediated Allele Detail
Summary
Symbol: Zmynd8em1Lwb
Name: zinc finger, MYND-type containing 8; endonuclease-mediated mutation 1, Weibo Luo
MGI ID: MGI:7431277
Synonyms: Zmynd8fl
Gene: Zmynd8  Location: Chr2:165626072-165740896 bp, - strand  Genetic Position: Chr2, 85.98 cM, cytoband H3
Alliance: Zmynd8em1Lwb page
Mutation
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, No functional change)
Mutation:    Insertion
    CRISPR-targeting generated a floxed allele. (J:326848)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: C57BL/6N * CBA * FVB
 
involves: C57BL/6N * FVB
 
Phenotypes:
Affected Systems
show or hide all annotated terms
   
endocrine/exocrine glands
decreased mammary gland tumor incidence
integument
decreased mammary gland tumor incidence
neoplasm
decreased mammary gland tumor incidence
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zmynd8 Mutation:  504 strains or lines available
References
Original:  J:326848 Luo M, et al., ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells. Sci Adv. 2022 Jul 15;8(28):eabn5295
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory