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Foxn4em1(IMPC)Ccpcz
Endonuclease-mediated Allele Detail
Summary
Symbol: Foxn4em1(IMPC)Ccpcz
Name: forkhead box N4; endonuclease-mediated mutation 1, Institute of Molecular Genetics
MGI ID: MGI:7431369
Gene: Foxn4  Location: Chr5:114392225-114411868 bp, - strand  Genetic Position: Chr5, 55.99 cM
Alliance: Foxn4em1(IMPC)Ccpcz page
IMPC: Foxn4 gene page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Inheritance:    Not Specified
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
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Source:
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IMPC - CCP-IMG
IMPC - CCP-IMG
IMPC - CCP-IMG
adipose tissue
increased total body fat amount
behavior/neurological
increased freezing behavior
no spontaneous movement
cardiovascular system
abnormal retina vasculature morphology
craniofacial
abnormal cranium morphology
abnormal tooth color
growth/size/body
abnormal tooth color
decreased lean body mass
hematopoietic system
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
abnormal spleen morphology
immune system
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
abnormal spleen morphology
integument
abnormal skin morphology
nervous system
decreased prepulse inhibition
skeleton
abnormal cranium morphology
abnormal tooth color
vision/eye
abnormal retina vasculature morphology
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxn4 Mutation:  32 strains or lines available
References
Original:  J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory