Foxn4^{em1(IMPC)Ccpcz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Foxn4^{em1(IMPC)Ccpcz}
• Name: forkhead box N4; endonuclease-mediated mutation 1, Institute of Molecular Genetics
• MGI ID: MGI:7431369
• Gene: Foxn4 Location: Chr5:114392225-114411868 bp, - strand Genetic Position: Chr5, 55.99 cM
• Alliance: Foxn4^{em1(IMPC)Ccpcz} page
• IMPC: Foxn4 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Inheritance: Not Specified

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Foxn4^em1(IMPC)Ccpcz/Foxn4^em1(IMPC)Ccpcz	C57BL/6NCrl-Foxn4^em1(IMPC)Ccpcz/Ccpcz
ht2	Foxn4^em1(IMPC)Ccpcz/Foxn4^+	C57BL/6NCrl-Foxn4^em1(IMPC)Ccpcz/Ccpcz

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms Sex:
Source:	IMPC - CCP-IMG	IMPC - CCP-IMG	IMPC - CCP-IMG
adipose tissue			√
increased total body fat amount			√
behavior/neurological	√	√
increased freezing behavior		√
no spontaneous movement	√
cardiovascular system			√
abnormal retina vasculature morphology			√
craniofacial		√	√
abnormal cranium morphology		√	√
abnormal tooth color			√
growth/size/body			√
abnormal tooth color			√
decreased lean body mass			√
hematopoietic system		√	√
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number		√
abnormal spleen morphology			√
immune system		√	√
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number		√
abnormal spleen morphology			√
integument			√
abnormal skin morphology			√
nervous system		√
decreased prepulse inhibition		√
skeleton		√	√
abnormal cranium morphology		√	√
abnormal tooth color			√
vision/eye			√
abnormal retina vasculature morphology			√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxn4 Mutation: 32 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)