Gtf2a1l^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gtf2a1l^em1(IMPC)J
• Name: general transcription factor IIA, 1-like; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7431467
• Gene: Gtf2a1l Location: Chr17:88976088-89022580 bp, + strand Genetic Position: Chr17, 58.22 cM, cytoband E5
• Alliance: Gtf2a1l^em1(IMPC)J page
• IMPC: Gtf2a1l gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ACTTACTGGCTCCATCTGAG and CACTGAGGCTGACAACCGGG, which resulted in a 406 bp deletion beginning at Chromosome 17 position 88,689,780 bp and ending after 88,690,185 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000138840 (exon 4) and 350 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 81 and early truncation 83 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gtf2a1l Mutation: 31 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)