Rr229173^em1Fena
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr229173^em1Fena
• Name: regulatory region 229173; endonuclease-mediated mutation 1, Felix Naef
• MGI ID: MGI:7432343
• Synonyms: Cry1deltae
• Gene: Rr229173 Location: Chr10:84995202-85001599 bp, . strand Genetic Position: Chr10, Syntenic
• Alliance: Rr229173^em1Fena page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: The Cry1 circadian rhythm enhancer in Cry1 intron 1 was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a 300 bp deletion. The deletion affects Cry1 transcription and transcription of other circadian rhythm related genes. (J:272434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr229173 Mutation: 0 strains or lines available

References

• Original: J:272434 Mermet J, et al., Clock-dependent chromatin topology modulates circadian transcription and behavior. Genes Dev. 2018 Mar 1;32(5-6):347-358
• All: 1 reference(s)