Adissp^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Adissp^{tm1c(EUCOMM)Hmgu}
• Name: adipose secreted signaling protein; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:7432545
• Synonyms: Adissp flox
• Gene: Adissp Location: Chr2:130988244-131002001 bp, - strand Genetic Position: Chr2, 63.28 cM, cytoband F3
• Alliance: Adissp^{tm1c(EUCOMM)Hmgu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332979
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The L1L2_gt1 cassette was inserted at position 130993292 of Chromosome 2 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 3 at position 130994101. The critical exon 3 is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ/neomycin sequence and generated a "conditional ready" (floxed) allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:332979)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adissp Mutation: 23 strains or lines available

References

• Original: J:332979 Chen Q, et al., A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis. Nat Commun. 2022 Dec 10;13(1):7633
• All: 1 reference(s)