Tg(APOE-rtTA,tetO-cre)1515-3Reh
Transgene Detail

Summary

• Symbol: Tg(APOE-rtTA,tetO-cre)1515-3Reh
• Name: transgene insertion 1515-3, Robert E Hammer
• MGI ID: MGI:7432912
• Synonyms: ApoE-rtTA:TRE2-Cre
• Transgene: Tg(APOE-rtTA,tetO-cre)1515-3Reh Location: unknown
• Alliance: Tg(APOE-rtTA,tetO-cre)1515-3Reh page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(APOE-rtTA,tetO-cre)1515-3Reh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  bacteria	tetO

• Mutation details: The transgenic construct is designed to have the promoter, intron 1 and hepatic control region (HCR) of the human apolipoprotein E gene driving expression of the reverse tetracycline-controlled transactivator (rtTA*M2) promoter element. The 2.8kb TRE-Cre transgenic construct is designed to have Cre recombinase under the control of tetO (tet-responsive element; TRE2). These constructs were coinjected into one-cell B6SJLF2 embryos. Both transgenes integrated at the same site in founder line 1515-3 mice. (J:332969)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	tetO (bacteria) Summary of all recombinase alleles driven by tetO.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:332969 Comerford SA, et al., Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent. PLoS Genet. 2023 Jan;19(1):e1010595
• All: 1 reference(s)