Slc12a8^{em2(cre/ERT2)Imai}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc12a8^{em2(cre/ERT2)Imai}
• Name: solute carrier family 12 (potassium/chloride transporters), member 8; endonuclease-mediated mutation 2, Shin-ichiro Imai
• MGI ID: MGI:7432978
• Synonyms: Slc12a8-CreERT2
• Gene: Slc12a8 Location: Chr16:33337698-33484505 bp, + strand Genetic Position: Chr16, 24.12 cM
• Alliance: Slc12a8^{em2(cre/ERT2)Imai} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Slc12a8^{em2(cre/ERT2)Imai} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc12a8 (MGI:2443672)

• Mutation details: The P2A followed by cre/ERT2 sequence was inserted downstream of the Slc12a8 gene by CRISPR/Cas9 system. (J:333074)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc12a8 (mouse) Summary of all recombinase alleles driven by Slc12a8. Comparative matrix view of recombinase activities Alliance mouse Slc12a8 gene page

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a8 Mutation: 32 strains or lines available

References

• Original: J:333074 Ito N, et al., Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging. Cell Rep. 2022 Jul 26;40(4):111131
• All: 1 reference(s)