Hoxa13^{tm1.1(cre)Mlkn}
Targeted Allele Detail

Summary

• Symbol: Hoxa13^{tm1.1(cre)Mlkn}
• Name: homeobox A13; targeted mutation 1.1, Mark L Kahn
• MGI ID: MGI:7433099
• Synonyms: Hoxa13Cre
• Gene: Hoxa13 Location: Chr6:52235833-52237865 bp, - strand Genetic Position: Chr6, 25.41 cM
• Alliance: Hoxa13^{tm1.1(cre)Mlkn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332098
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Hoxa13^{tm1.1(cre)Mlkn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxa13 (MGI:96173)

• Mutation details: A T2A-fused Cre coding region, and a flippase recombination target (FRT)flanked WPRE-pA and neomycin resistance cassette were inserted into the exon 2 of the Hoxa13 gene. FLPo recombinase removed the sequences flanked by FRT sites, which includes neo cassette, exogenous PolyA and WPRE. (J:332098)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxa13 (mouse) Summary of all recombinase alleles driven by Hoxa13. Comparative matrix view of recombinase activities Alliance mouse Hoxa13 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa13 Mutation: 29 strains or lines available

References

• Original: J:332098 Chen X, et al., Mouse placenta fetal macrophages arise from endothelial cells outside the placenta. Dev Cell. 2022 Dec 5;57(23):2652-2660.e3
• All: 1 reference(s)