Cd34^{tm1.1(cre/ERT2)Lizg}
Targeted Allele Detail

Summary

• Symbol: Cd34^{tm1.1(cre/ERT2)Lizg}
• Name: CD34 antigen; targeted mutation 1.1, Li Zhang
• MGI ID: MGI:7434546
• Synonyms: Cd34-CreER^T2
• Gene: Cd34 Location: Chr1:194621239-194643587 bp, + strand Genetic Position: Chr1, 98.38 cM
• Alliance: Cd34^{tm1.1(cre/ERT2)Lizg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324286
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cd34^{tm1.1(cre/ERT2)Lizg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd34 (MGI:88329)

• Mutation details: By conventional embryonic stem cell gene targeting, CreERT2 fusion protein was inserted into the ATG start codon of the Cd34 gene. (J:324286)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd34 (mouse) Summary of all recombinase alleles driven by Cd34. Comparative matrix view of recombinase activities Alliance mouse Cd34 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd34 Mutation: 33 strains or lines available

References

• Original: J:324286 Jiang L, et al., Nonbone Marrow CD34(+) Cells Are Crucial for Endothelial Repair of Injured Artery. Circ Res. 2021 Oct;129(8):e146-e165
• All: 2 reference(s)