Rr303293^tm1Jta
Targeted Allele Detail

Summary

• Symbol: Rr303293^tm1Jta
• Name: regulatory region 303293; targeted mutation 1, Jussi Taipale
• MGI ID: MGI:7434646
• Synonyms: Myc-CTCF^mut
• Gene: Rr303293 Location: Chr15:61854801-61855400 bp, . strand Genetic Position: Chr15, Syntenic
• Alliance: Rr303293^tm1Jta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257088
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The Myc-related CTCF-binding site was mutated from TGGCCAGTAGAGGGCAC to TGGAACGTCTTGAATGC and a loxP site was inserted upstream of the mutation. The mutation prevents this region from acting as an insulator. (J:257088)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr303293 Mutation: 0 strains or lines available

References

• Original: J:257088 Dave K, et al., Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth. Elife. 2017 Jun 6;6:e23382
• All: 1 reference(s)