Drd2^em1(cre)Phsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Drd2^em1(cre)Phsh
• Name: dopamine receptor D2; endonuclease-mediated mutation 1, Minoru Narita
• MGI ID: MGI:7434696
• Synonyms: D2-cre, Drd2^tm1(cre)Phsh
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^em1(cre)Phsh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Drd2^em1(cre)Phsh expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Drd2 (MGI:94924)

• Using CRISPR/Cas9 technology, cre coding sequence was inserted into the Drd2 gene. (J:333162)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Drd2 (mouse) Summary of all recombinase alleles driven by Drd2. Comparative matrix view of recombinase activities Alliance mouse Drd2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:333162 Sato D, et al., Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens. Mol Brain. 2022 Feb 16;15(1):17
• All: 1 reference(s)