Mmp25^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mmp25^em1(IMPC)J
• Name: matrix metallopeptidase 25; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:7434718
• Gene: Mmp25 Location: Chr17:23847289-23864006 bp, - strand Genetic Position: Chr17, 11.87 cM
• Alliance: Mmp25^em1(IMPC)J page
• IMPC: Mmp25 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TGCAATTTAGGCACTCCCTG and GGAATACTGTCTCTATCAGG, which resulted in a 638 bp deletion beginning at Chromosome 17 position 23643797 bp and ending after 23644434 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000136262 (exon 2) and 505 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 88 and early truncation 2 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mmp25 Mutation: 34 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)