Lypd4^em1Eyx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lypd4^em1Eyx
• Name: Ly6/Plaur domain containing 4; endonuclease-mediated mutation 1, Eugene Yujun Xu
• MGI ID: MGI:7435025
• Synonyms: Lypd4^-
• Gene: Lypd4 Location: Chr7:24564044-24569180 bp, - strand Genetic Position: Chr7, 13.3 cM
• Alliance: Lypd4^em1Eyx page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a null mutation. Mutagenesis resulted in two deletions in exon 3, including one 15bp deletion and a second 76bp deletion. (J:294725)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lypd4 Mutation: 19 strains or lines available

References

• Original: J:294725 Wang D, et al., LYPD4, mouse homolog of a human acrosome protein, is essential for sperm fertilizing ability and male fertility. Biol Reprod. 2020 Apr 24;102(5):1033-1044
• All: 1 reference(s)