Slc6a2^{em1(cre)Zhanc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc6a2^{em1(cre)Zhanc}
• Name: solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; endonuclease-mediated mutation 1, Cheng Zhan
• MGI ID: MGI:7435059
• Synonyms: Net-Cre
• Gene: Slc6a2 Location: Chr8:93687100-93728295 bp, + strand Genetic Position: Chr8, 44.99 cM
• Alliance: Slc6a2^{em1(cre)Zhanc} page

Mutation origin

• Strain of Origin: CD1F1

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Slc6a2^{em1(cre)Zhanc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a2 (MGI:1270850)

• Mutation details: The Cre coding sequence was inserted after the initiation codon of the Slc6a2 (Net) using the CRISPR technology. Cre is primarily expressed in the locus coeruleus. (J:333232)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a2 (mouse) Summary of all recombinase alleles driven by Slc6a2. Comparative matrix view of recombinase activities Alliance mouse Slc6a2 gene page

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a2 Mutation: 35 strains or lines available

References

• Original: J:333232 Chen J, et al., A Vagal-NTS Neural Pathway that Stimulates Feeding. Curr Biol. 2020 Oct 19;30(20):3986-3998.e5
• All: 1 reference(s)