Vdr^em1(cre)Ssis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vdr^em1(cre)Ssis
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; endonuclease-mediated mutation 1, Stephanie Sisley
• MGI ID: MGI:7435234
• Synonyms: VDR^Cre
• Gene: Vdr Location: Chr15:97752308-97806177 bp, - strand Genetic Position: Chr15, 53.85 cM
• Alliance: Vdr^em1(cre)Ssis page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Vdr^em1(cre)Ssis expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Vdr (MGI:103076)

• Mutation details: Using CRISPR/Cas9 technology, a V5 tag with a GGGGS linker followed by a P2A sequence and Cre-recombinase were inserted into the C-terminal end of the Vdr gene. (J:333277)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Vdr (mouse) Summary of all recombinase alleles driven by Vdr. Comparative matrix view of recombinase activities Alliance mouse Vdr gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdr Mutation: 36 strains or lines available

References

• Original: J:333277 Liu H, et al., Defining vitamin D receptor expression in the brain using a novel VDR(Cre) mouse. J Comp Neurol. 2021 Jun;529(9):2362-2375
• All: 1 reference(s)