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Lztfl1tm1.1Zpl
Targeted Allele Detail
Summary
Symbol: Lztfl1tm1.1Zpl
Name: leucine zipper transcription factor-like 1; targeted mutation 1.1, Zhi-Ping Liu
MGI ID: MGI:7435271
Synonyms: Lztfl1tm1b
Gene: Lztfl1  Location: Chr9:123523469-123546690 bp, - strand  Genetic Position: Chr9, 74.36 cM, cytoband F
Alliance: Lztfl1tm1.1Zpl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:287261
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe KOMP L1L2_Pgk_P cassette L3L4_pD223_DTA_spec backbone from project CSD50165 was used to generate this allele. The cassette is composed of an FRT site followed by a lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, sV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4. The critical exon 4 is thus flanked by loxP sites. Exon 4 and the neomycin resistance gene were removed via cre-mediated recombination generating a reporter knock-out mouse. Western blot analysis confirmed absence of protein in brain tissue lysates. (J:287261)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lztfl1 Mutation:  20 strains or lines available
References
Original:  J:287261 Wei Q, et al., Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons. J Mol Cell Biol. 2018 Oct 1;10(5):402-410
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory