Lztfl1tm1.1Zpl
Targeted Allele Detail
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Symbol: |
Lztfl1tm1.1Zpl |
Name: |
leucine zipper transcription factor-like 1; targeted mutation 1.1, Zhi-Ping Liu |
MGI ID: |
MGI:7435271 |
Synonyms: |
Lztfl1tm1b |
Gene: |
Lztfl1 Location: Chr9:123523469-123546690 bp, - strand Genetic Position: Chr9, 74.36 cM, cytoband F
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Alliance: |
Lztfl1tm1.1Zpl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:287261
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Parent Cell Line: |
JM8 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The KOMP L1L2_Pgk_P cassette L3L4_pD223_DTA_spec backbone from project CSD50165 was used to generate this allele. The cassette is composed of an FRT site followed by a lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, sV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4. The critical exon 4 is thus flanked by loxP sites. Exon 4 and the neomycin resistance gene were removed via cre-mediated recombination generating a reporter knock-out mouse. Western blot analysis confirmed absence of protein in brain tissue lysates.
(J:287261)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lztfl1 Mutation: |
20 strains or lines available
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Original: |
J:287261 Wei Q, et al., Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons. J Mol Cell Biol. 2018 Oct 1;10(5):402-410 |
All: |
1 reference(s) |
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