Rr364^tm1.1Aak
Targeted Allele Detail

Summary

• Symbol: Rr364^tm1.1Aak
• Name: regulatory region 364; targeted mutation 1.1, Ahmed Khamlichi
• MGI ID: MGI:7435285
• Synonyms: 5'hs1RI^delta
• Gene: Rr364 Location: Chr12:113221060-113221106 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr364^tm1.1Aak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242276
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The CTCF-binding insulator in the last intron of Igha was deleted and a loxP site flanked neomycin resistance gene cassette was inserted downstream of Igha (but upstream of enhancer 3'RR (Rr152)). The neo cassette was removed through subsequent cre-mediated recombination. (J:242276)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr364 Mutation: 0 strains or lines available

References

• Original: J:242276 Braikia FZ, et al., Inducible CTCF insulator delays the IgH 3' regulatory region-mediated activation of germline promoters and alters class switching. Proc Natl Acad Sci U S A. 2017 Jun 06;114(23):6092-6097
• All: 1 reference(s)