Ltf^tm1(cre)Stw
Targeted Allele Detail

Summary

• Symbol: Ltf^tm1(cre)Stw
• Name: lactotransferrin; targeted mutation 1, Colin L Stewart
• MGI ID: MGI:7437636
• Synonyms: CB4, LtfCre (CB4)
• Gene: Ltf Location: Chr9:110848360-110871834 bp, + strand Genetic Position: Chr9, 60.79 cM, cytoband F
• Alliance: Ltf^tm1(cre)Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245455
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Ltf^tm1(cre)Stw expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ltf (MGI:96837)

• Mutation details: The targeting vector consisting of a Cre-pA followed by a neomycin (neo) cassette under the control of the PGK promoter inserted into the endogenous lactoferrin gene just downstream of the ATG start site was used for the homologous recombination in the ES cells. (J:245455)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ltf (mouse) Summary of all recombinase alleles driven by Ltf. Comparative matrix view of recombinase activities Alliance mouse Ltf gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltf Mutation: 41 strains or lines available

References

• Original: J:245455 Cheng J, et al., Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure. Endocrinology. 2017 Jun 01;158(6):1916-1928
• All: 1 reference(s)