Twist2^{tm1(cre/ERT2)Eno}
Targeted Allele Detail

Summary

• Symbol: Twist2^{tm1(cre/ERT2)Eno}
• Name: twist basic helix-loop-helix transcription factor 2; targeted mutation 1, Eric N Olson
• MGI ID: MGI:7437699
• Synonyms: Tw2-CreERT2, Tw2-CreERT2-neo
• Gene: Twist2 Location: Chr1:91729183-91775750 bp, + strand Genetic Position: Chr1, 46.24 cM
• Alliance: Twist2^{tm1(cre/ERT2)Eno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246973
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Twist2^{tm1(cre/ERT2)Eno} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Twist2 (MGI:104685)

• A CreERT2-Frt-Neo-Frt expression cassette was inserted to replace exon 1 of the Twist2 gene. (J:246973)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Twist2 (mouse) Summary of all recombinase alleles driven by Twist2. Comparative matrix view of recombinase activities Alliance mouse Twist2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Twist2 Mutation: 10 strains or lines available

References

• Original: J:246973 Liu N, et al., A Twist2-dependent progenitor cell contributes to adult skeletal muscle. Nat Cell Biol. 2017 Mar;19(3):202-213
• All: 2 reference(s)