Gt(ROSA)26Sor^{tm1(ADGRG6)Jlp}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(ADGRG6)Jlp}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jose Luis de la Pompa
• MGI ID: MGI:7438178
• Synonyms: GPR126^GOF
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(ADGRG6)Jlp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315981
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A loxP flanked PGK-neomycin resistance gene/STOP cassette, human ADGRG6 cDNA, and an internal ribosome entry site (IRES) fused to GFP were inserted into the locus. (J:315981)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:315981 Torregrosa-Carrion R, et al., Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Sci Adv. 2021 Nov 12;7(46):eabj5445
• All: 1 reference(s)