Setd5^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Setd5^{tm1c(EUCOMM)Wtsi}
• Name: SET domain containing 5; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7438258
• Synonyms: Setd5^Fl
• Gene: Setd5 Location: Chr6:113054326-113130393 bp, + strand Genetic Position: Chr6, 52.73 cM, cytoband E3
• Alliance: Setd5^{tm1c(EUCOMM)Wtsi} page
• IMPC: Setd5 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314464
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt2 cassette was inserted at position 113086383 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 113088756. The critical exon(s) is/are thus flanked by loxP sites. The lacZ/neomycin sequence was removed via flp-mediated recombination generating a conditional ready (floxed) allele. (J:314464)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd5 Mutation: 122 strains or lines available

References

• Original: J:314464 Cheung MY, et al., Setd5 is required in cardiopharyngeal mesoderm for heart development and its haploinsufficiency is associated with outflow tract defects in mouse. Genesis. 2021 Aug;59(7-8):e23421
• All: 1 reference(s)