Iigp1c^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Iigp1c^M1Btlr
• Name: interferon inducible GTPase 1C; mutation 1, Bruce Beutler
• MGI ID: MGI:7439057
• Synonyms: Gm4951^M1Btlr, Gm4951^Oily
• Gene: Iigp1c Location: Chr18:60345152-60380892 bp, + strand Genetic Position: Chr18, 34.36 cM
• Alliance: Iigp1c^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis produced a point mutation that results in the amino acid substitution of asparagine with lysine at position 86 (N86K). (J:333470)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iigp1c Mutation: 16 strains or lines available

References

• Original: J:333470 Zhang Z, et al., Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Nat Commun. 2022 Jul 16;13(1):4136
• All: 1 reference(s)