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Iigp1cM2Btlr
Chemically induced Allele Detail
Summary
Symbol: Iigp1cM2Btlr
Name: interferon inducible GTPase 1C; mutation 2, Bruce Beutler
MGI ID: MGI:7439058
Synonyms: Gm4951Carboniferous, Gm4951M2Btlr
Gene: Iigp1c  Location: Chr18:60345152-60380892 bp, + strand  Genetic Position: Chr18, 34.36 cM
Alliance: Iigp1cM2Btlr page
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU) (Null/knockout)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis produced a point mutation that results in the amino acid substitution of aspartic acid with glycine at position 125 (D125G). (J:333470)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Iigp1c Mutation:  16 strains or lines available
References
Original:  J:333470 Zhang Z, et al., Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity. Nat Commun. 2022 Jul 16;13(1):4136
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory